Jennifer Lawrence
as Kate Dibiasky
Leonardo DiCaprio
as Dr. Randall Mindy
Meryl Streep
as President Orlean
Rob Morgan
as Dr. Teddy Oglethorpe
Jonah Hill
as Jason Orlean
Cate Blanchett
as Brie Evantee
Mark Rylance
as Peter Isherwell
Tyler Perry
as Jack Bremmer
Timothée Chalamet
as Yule
Ron Perlman
as Benedict Drask
Ariana Grande
as Riley Bina
Kid Cudi
as DJ Chello
Himesh Patel
as Phillip
Melanie Lynskey
as June Mindy
Michael Chiklis
as Dan Pawketty
Tomer Sisley
as Adul Grelio
Paul Guilfoyle
as General Themes
Robert Joy
as Congressman Tenant
Jack Alberts
as Oliver
Ting Lik
as Win
Lance A. Williams
as Daniel
Shimali de Silva
as Nisha
Hettienne Park
as Dr. Calder
Rafael Silva
as Nasa Scientist
Lonnie Farmer
as Old Aide #1
Homa Sarabi Daunis
as White House Office Worker
Barbara Douglass
as Office Worker
Rena Maliszewski
as Anchor Reporting On Colon
Erik Parillo
as Sherriff Conlon
Robert Hurst Radochia
as Evan Mindy
Conor Sweeney
as Marshall Mindy
Ross Partridge
as Keith Ollens
Richard Donelly
as Old Aide #2
Liev Schreiber
as Bash Narrator (voice)
Samsara Yett
as Isherwell Child Aide
Meara Mahoney Gross
as Isherwell Child Aide
Jaden Onwuakor
as Isherwell Child Aide
Staci Roberts
as Linda Dicalio
Wendy Bellevue
as Isherwell Child Handler
Mishka Yarovoy
as Executive
Chris Everett
as Chief Editor Paula Woods
Annette Miller
as Mrs. Tanken
Stephen Thorne
as Benjamin
Aimee Doherty
as Passerby
Natalie Rebenkoff
as Talent PA
Gary Tanguay
as News Anchor #2
Georgia Lyman
as Groomer Thalia
Patricia DeHaney
as Hair Person
Ben Sidell
as Stage Manager
Therese Plaehn
as Autopsy Editor In Charge
Omar Ghonim
as Damian
Jody O'Neil
as Stage Manager #2
Meghan Leathers
as Media Quant
Ashleigh Banfield
as Dalia Hensfield
Sarah Silverman
as Sarah Benterman
Richard Snee
as Senator Lerner
Darryl Wooten
as FBI Agent
Danielle Waxman
as College Girl
Jeffrey Smith
as Blind Man FBI Agent
Jon Glaser
as Meow Man
Dorothy Dwyer
as Old Tough Lady
Odis Spencer Jr.
as Chief Justice
Chris Evans
as Devin Peters (uncredited)
André Silva
Not known
Lewis D. Wheeler
as Mission Coordinator
Zach Holmes
as #LaunchChallenge MeTuber (uncredited)
Caroline Bergwall
as Teen Girl Friend
Luan Gallagher
as Figurante
Ishaan Khattar
as Raghav Manavalan